Isolated Heart QT Prolongation Assays
If your drug has a positive hERG signal, does it have a QT Risk?
The CT-QT™ Assay is more than a QT Measurement.
Benefits:
- Paced heart model – No QT correction required.
- Measures drug effects on isolated rabbit hearts:
- CT-QT™ Screen: QT only; or
- CT-QT™: QT, plus contractility (LVP, dP/dtmax & dP/dtmin) & MAPD
- GLP & non-GLP protocols available
- Positive & vehicle controls
- Performed at physiological temperature 37 + 1° C
| Standard Assay Parameters | ||
| Protocol | GLP or Non-GLP |
Screen |
| Number of concentrations tested | 3 |
3 |
| Number of hearts per concentration | 4 |
3 |
Additional Options:
- Dose Solution Analysis – GLP & non-GLP; verify applied concentrations
- Coronary Blood Flow & QRS Data – quoted by study
- Additional copies of final report (one provided with study)
- Copies of solution worksheets and data collection forms
- Electronic copy of report (pdf) on CD-ROM
- Nonclinical Integrated Risk Assessment report – data from ChanTest dose-response & repolarization reports, plus sponsor’s effective therapeutic plasma concentration data, compiled into one report