The CB2 cannabinoid receptor is expressed primarily in cells of the peripheral immune system and is a target for cannabinoids (Munro et al., 1993; Gerard et al., 1991), the psychoactive ingredients of marijuana. Other members of the cannabinoid family of receptors include the CB1 cannabinoid receptor, which is expressed primarily in brain, and GPR55 (Ryberg, 2007). When activated, the CB2 receptor inhibits adenylate cyclase by coupling through Gi.
|Product Description||Frozen membranes from CHO-K1 cells expressing recombinant rat CB2 Cannabinoid receptors.|
|Therapeutic Area||neurodegeneration & stroke, pain & inflammation|
|Related Services||Membrane Preparation, GPCR Screening|
|Genbank Accession Number||AF176350|
|References||Munro,S., et al., (1993) Molecular characterization of a peripheral receptor for Cannabinoids Nature 365:6441), 61-65 (1993)
Gerard, C.M et al. (1991) Molecular cloning of a human cannabinoid receptor which is also expressed in testis. Biochem. J.
|Mycoplasma Status||Negative (MycoAlert Kit)|
|Recommended Assay Conditions||Refer to product specification sheet for details|
|Storage and Packaging|
|Packaging||0.1 mL of membrane suspension in storage buffer (20 mM HEPES, pH 7.4, 0.1 mM EDTA, 10% sucrose) at a protein concentration of 10 mg/mL.|
|Storage Recommendation||-80°C; Avoid repeated freeze-thawing of this product.|
|Specification Sheet||Download PDF Document|