Human NCX1 Na<sup>+</sup>/Ca<sup>2+</sup> Exchanger Cell Line

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  • KB-R7946 inhibition of NCX1 by measured with a calcium-sensitive dye assay in FLIPRTETRA®. Increasing concentrations of KB-R796 inhibited Ca2+ efflux (forward-mode Na+/Ca2+ exchange) in a concentration-dependent manner.
  • Concentration-response relationship for KB-R7946 inhibition. The IC50 value was 20.9 µM. Recording instrument: FLIPR®.

Human NCX1 Na+/Ca2+ Exchanger Cell Line

  • Cat.#:
  • CT6206

Availability: In stock

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Quick Overview

Human NCX1 Na+/Ca2+ Exhanger-expressing, stable replicating cell line.

Background

The human NCX1 gene encodes the Na+/Ca2+ exchanger. NCX1 expressed in cardiac myocytes are therapeutic targets in heart disease.
General Info
Product Description Human NCX1 Na+/Ca2+ Exhanger-expressing, stable replicating cell line.
Target Type Exchanger
Product Type Replicating Cell Line
Family Exchanger
Sub-Type NCX1 Na+/Ca2+
Class Na+/Ca2+ exchange transporter
Therapeutic Area cardiac, vascular
Related Services Cardiac Ion Channel Panel™
Gene Name NCX1
Validated Assay/Platform FLIPR®
References Hilgemann DW. 2004. Am J Physiol Cell Physiol 287:C1167-C1172. New insights into the molecular and cellular workings of the cardiac Na+/Ca2+ exchanger.
Host cell HEK293
Mycoplasma Status Negative (MycoAlert Kit)
Storage & Packaging
Packaging Cryopreserved cells, 1-2x106 cells
Storage Recommendation liquid nitrogen
Quantity 1-2 million cells
Product Documentation
Specification Sheet  Download PDF Document