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Background
The human TRPC6 gene encodes the pore-forming subunit of TRPC6 (transient receptor potential channel, subtype C6), a non-selective, calcium-permeable cation channel. TRPC6 channels, activated via phospholipase C stimulation, are essential to receptor-operated Ca2+ influx in vascular smooth muscle.
| General Info | |
| Product Description | Human TRPC6 ion channel-expressing, transiently transfected cells. |
|---|---|
| Target Type | Ion Channel |
| Product Type | EZCells™ TT |
| Family | TRP |
| Sub-Type | TRPC6 |
| Class | Transient Receptor Potential (TRP) |
| Therapeutic Area | cancer, pulmonary-respiratory, vascular |
| Gene Name | TRPC6 |
| Genbank Accession Number | NM_004621.3 |
| Validated Assay/Platform | manual patch clamp |
| References | Clapham DE, et al. 2005. International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels. Pharmacol Rev 57: 427 - 450. Pedersen SF, Owsianik G, Nilius B. 2005. TRP channels: an ove |
| EZCell Info | |
| Host cell | HEK293 |
| Mycoplasma Status | Negative (MycoAlert Kit) |
| Growth media | DMEM/F12/10% FBS |
| Functional expression | Median current amplitude = 4 nA |
| Storage and Packaging | |
| Packaging | Cryopreserved cells, 6x106 cells/vial |
| Storage Recommendation | liquid nitrogen |
| Quantity | 6 million cells |
