My Cart
You have no items in your shopping cart.
Background
The human KCNQ1 gene encodes the pore-forming subunit of a voltage-gated potassium channel. Co-expression with minK, an auxiliary subunit, recapitulates native function in heterologous expression (CHO cells). KvLQT1/minK channels expressed in the heart are safety targets in congenital and acquired long QT syndromes.
| General Info | |
| Synonyms | Kv7.1/minK |
|---|---|
| Product Description | Human KvLQT1/minK ion channel-expressing, division-arrested cells. |
| Target Type | Ion Channel |
| Product Type | EZCells™ TT |
| Family | Potassium, Voltage-Gated |
| Sub-Type | KvLQT1/minK |
| Class | Voltage-gated potassium channel |
| Therapeutic Area | cardiac, vascular |
| Related Services | Cardiac Ion Channel Panel™, Ion Channel Trafficking Assays |
| Gene Name | KCNQ1/KCNE1 |
| Validated Assay/Platform | PatchXpress® |
| References | Gutman GA, et al. 2005. Pharmacol Rev. 57:473-508. International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. |
| EZCell Info | |
| Host cell | CHO |
| Mycoplasma Status | Negative (MycoAlert Kit) |
| Growth media | Ham's F12; 10% FBS |
| Growth characteristics | cells remain viable 1–2 days post-thaw |
| Functional expression | median K+ current amplitude =2.2 nA |
| Storage and Packaging | |
| Packaging | Cryopreserved irradiated cells, 6x106 cells |
| Storage Recommendation | liquid nitrogen |
| Quantity | 6 million cells |
