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Background
The human KCNQ1 gene encodes the pore-forming subunit of Kv7.1, a voltage-gated potassium channel. KCNE1 encodes an auxiliary subunit that modulates gating and pharmacological characteristics. Kv7.1/KCNE1 channels expressed in heart are safety targets in cardiac long-QT risk assessment.
| General Info | |
| Synonyms | KvLQT1/minK |
|---|---|
| Product Description | Human Kv7.1 potassium ion channel-expressing, stable replicating cell line. |
| Target Type | Ion Channel |
| Product Type | Replicating Cell Line |
| Family | Potassium, Voltage-Gated |
| Sub-Type | Kv7.1 |
| Class | Voltage-gated potassium channel |
| Therapeutic Area | cardiac, vascular |
| Related Services | Large-scale Cryopreservation |
| Gene Name | KCNQ1/KCNE1 |
| Validated Assay/Platform | IonWorks Quattro™, manual patch clamp, QPatch HT |
| References | Gutman GA, et al. 2005. Pharmacol Rev. 57:473-508. International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. |
| Host cell | CHO |
| Mycoplasma Status | Negative (MycoAlert Kit) |
| Storage & Packaging | |
| Packaging | Cryopreserved cells, 1-2x106 cells |
| Storage Recommendation | liquid nitrogen |
| Quantity | 1-2 million cells |
| Product Documentation | |
| Specification Sheet |  Download PDF Document |
