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Human Kv4.3 Potassium Channel Cell Line

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  • hKv4.3 current-voltage family recorded by PatchXpress®. Whole-cell currents were elicited by test pulses from -60 to +50 mV in 10 mV increments from holding potential, -80 mV.
  • Concentration-response relationship for flecainide inhibition of peak hKv4.3 currents at a test potential of +20 mV. The IC50 value was 47.5 µM. Recording instrument: PatchXpress®.

Human Kv4.3 Potassium Channel Cell Line

  • Cat.#:
  • CT6144

Availability: In stock

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Quick Overview

Human Kv4.3 potassium ion channel-expressing, stable replicating cell line (HEK).

Background

The human KCND3 gene encodes the pore-forming subunit of Kv4.3, a voltage-gated potassium channel. Kv4.3 channels expressed in heart are therapeutic targets in atrial fibrillation.
General Info
Product Description Human Kv4.3 potassium ion channel-expressing, stable replicating cell line (HEK).
Target Type Ion Channel
Product Type Replicating Cell Line
Family Potassium, Voltage-Gated
Sub-Type Kv4.3
Class Voltage-gated potassium channel
Therapeutic Area cardiac
Related Services Large-scale Cryopreservation
Gene Name KCND3
Validated Assay/Platform PatchXpress®
References Gutman GA, et al. 2005. Pharmacol Rev. 57:473-508. International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels.
Host cell HEK293
Mycoplasma Status Negative (MycoAlert Kit)
Storage & Packaging
Packaging Cryopreserved cells, 1-2x106 cells
Storage Recommendation liquid nitrogen
Quantity 1-2 million cells
Product Documentation
Specification Sheet  Download PDF Document