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Background
The human KCND2 gene encodes the pore-forming subunit of Kv4.2, a voltage-gated potassium channel. The KCNIP2 gene encodes an auxiliary subunit of the channel. Kv4.2/KChIP2.2 channels expressed in neurons are therapeutic targets in nociceptive and inflammatory pain.
| General Info | |
| Product Description | Human Kv4.2/KChIP2.2 potassium ion channel-expressing, stable replicating cell line (HEK). |
|---|---|
| Target Type | Ion Channel |
| Product Type | Replicating Cell Line |
| Family | Potassium, Voltage-Gated |
| Sub-Type | Kv4.2/KChIP2.2 |
| Class | Voltage-gated potassium channel |
| Therapeutic Area | pain & inflammation |
| Related Services | Large-scale Cryopreservation |
| Gene Name | KCND2/KCNIP2 |
| Validated Assay/Platform | manual patch clamp, PatchXpress®, QPatch HT |
| References | Gutman GA, et al. 2005. Pharmacol Rev. 57:473-508. International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. |
| Host cell | HEK293 |
| Mycoplasma Status | Negative (MycoAlert Kit) |
| Storage & Packaging | |
| Packaging | Cryopreserved cells, 1-2x106 cells |
| Storage Recommendation | liquid nitrogen |
| Quantity | 1-2 million cells |
| Product Documentation | |
| Specification Sheet |  Download PDF Document |
