Human Kv1.4 Potassium Channel Cell Line

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  • 4-Aminopyridine block of Kv1.4 channels. hKv1.4 currents recorded by QPatch™HT. Whole-cell currents were elicited by test pulses to +20 mV from holding potential, ‑80 mV, before and after application of 1 mM 4-AP.
  • Concentration-response relationship for 4-aminopyridine inhibition of peak hKv1.4 currents. The IC50 value was 0.5 mM. Recording instrument: QPatch HT™.

Human Kv1.4 Potassium Channel Cell Line

  • Cat.#:
  • CT6135

Availability: In stock

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Quick Overview

Human Kv1.4 potassium ion channel-expressing, stable replicating cell line (CHO).

Background

The human KCNA4 gene encodes the pore-forming subunit of Kv1.4, a voltage-gated potassium channel. Kv1.4 channels expressed in neurons are therapeutic targets in neuropathic pain.
General Info
Product Description Human Kv1.4 potassium ion channel-expressing, stable replicating cell line (CHO).
Target Type Ion Channel
Product Type Replicating Cell Line
Family Potassium, Voltage-Gated
Sub-Type Kv1.4
Class Voltage-gated potassium channel
Therapeutic Area pain & inflammation
Related Services Large-scale Cryopreservation
Gene Name KCNA4
Validated Assay/Platform IonWorks Quattro™, QPatch HT
References Gutman GA, et al. 2005. Pharmacol Rev. 57:473-508. International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels.
Host cell CHO-K1
Mycoplasma Status Negative (MycoAlert Kit)
Storage & Packaging
Packaging Cryopreserved cells, 1-2x106 cells
Storage Recommendation liquid nitrogen
Quantity 1-2 million cells
Product Documentation
Specification Sheet  Download PDF Document