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Background
The human KCNJ3 and KCNJ5 genes encode the pore-forming subunits of heteromeric Kir3.1/Kir3.4, an inward rectifier potassium channel. Kir3.1/Kir3.4 channels expressed in heart are linked to M2 muscarinic acetylcholine receptors that mediate vagal inhibitory control of heart rate. Kir3.1/Kir3.4 is a potential target for treatment of atrial fibrillation.
| General Info | |
| Product Description | Human Kir3.1/Kir3.4 potassium ion channel-expressing, stable replicating cell line. |
|---|---|
| Target Type | Ion Channel |
| Product Type | Replicating Cell Line |
| Family | Potassium, Inward Rectifier |
| Sub-Type | Kir3.1/Kir3.4 |
| Class | Inward rectifier potassium channel |
| Related Services | Cardiac Ion Channel Panel™, Large-scale Cryopreservation |
| Gene Name | KCNJ3/KCNJ5 |
| Validated Assay/Platform | PatchXpress® |
| References | Kubo Y, et al. 2005. Pharmacol Rev. 57:509-526. International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels. |
| Host cell | HEK293 |
| Mycoplasma Status | Negative (MycoAlert Kit) |
| Storage & Packaging | |
| Packaging | Cryopreserved cells, 1-2x106 cells |
| Storage Recommendation | liquid nitrogen |
| Quantity | 1-2 million cells |
| Product Documentation | |
| Specification Sheet |  Download PDF Document |
