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Background
The human KCNN4 gene encodes the pore-forming subunit of KCa3.1, the calcium-activated IK potassium channel. KCa3.1 channels expressed in lymphocytes, fibroblasts, proliferating vascular smooth muscle cells, vascular endothelium and, intestinal and airway epithelia are therapeutic targets in inflammatory diseases in these tissues. KCa3.1 channels expressed in erthrocytes have been investigated as targets for treatment of sickle cell anemia.
| General Info | |
| Synonyms | IK |
|---|---|
| Product Description | Human kCa3.1 potassium ion channel-expressing, stable replicating cell line. |
| Target Type | Ion Channel |
| Product Type | Replicating Cell Line |
| Family | Potassium, Calcium-Activated |
| Sub-Type | KCa3.1 |
| Class | Calcium-activated potassium channel |
| Therapeutic Area | cancer, genitourinary, pain & inflammation, pulmonary-respiratory, vascular |
| Related Services | Large-scale Cryopreservation |
| Gene Name | KCNN4 |
| Validated Assay/Platform | PatchXpress®, QPatch HT |
| References | Wei AD, et al. 2005. Pharmacol Rev. 57:463-472. International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium activated-potassium channels. |
| Host cell | CHO-K1 |
| Mycoplasma Status | Negative (MycoAlert Kit) |
| Storage & Packaging | |
| Packaging | Cryopreserved cells, 1-2x106 cells |
| Storage Recommendation | liquid nitrogen |
| Quantity | 1-2 million cells |
| Product Documentation | |
| Specification Sheet |  Download PDF Document |
