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Background
The KCNN1 gene encodes the pore-forming subunit of a small-conductance (2 - 3 pS single channel conductance), K+-selective, channel that is activated by increased intracellular [Ca2+]. Expressed in neurons, hKCa2.1 channels contribute to the afterhyperpolarization that modulates repetitive firing frequency.
| General Info | |
| Synonyms | SK1 |
|---|---|
| Product Description | Human KCa2.1 ion channel-expressing, division-arrested cells. |
| Target Type | Ion Channel |
| Product Type | EZCells™ TT |
| Family | Potassium, Calcium-Activated |
| Sub-Type | KCa2.1 |
| Class | calcium-activated potassium channel |
| Therapeutic Area | neurodegeneration & stroke, psychiatric disorder |
| Gene Name | KCNN1 |
| Validated Assay/Platform | manual patch clamp |
| References | Wei AD, et al. International Union of Pharmacology. LII. 2005. Nomenclature and molecular relationships of calcium-activated potassium channels. Pharmacol Rev. 57:463-472. |
| EZCell Info | |
| Host cell | CHO-K1 |
| Mycoplasma Status | Negative (MycoAlert Kit) |
| Growth media | Ham's F12; 10% FBS |
| Growth characteristics | Cells remain viable 1–2 days post-thaw |
| Functional expression | Mean apamin-sensitive current amplitude ± SEM in QPatch™ at +40 mV = 194 ± 51pA (n = 12 cells). |
| Storage and Packaging | |
| Packaging | Cryopreserved irradiated cells, 6x106 cells |
| Storage Recommendation | liquid nitrogen |
| Quantity | 6 million cells |
