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Background
The KCNM1 gene encodes the pore-forming subunit of a large-conductance (260 pS single channel conductance), K+ -selective, channel that is activated by membrane depolarization and increased intracellular [Ca2+].
| General Info | |
| Synonyms | BK, maxi-K |
|---|---|
| Product Description | Human KCa1.1 potassium ion channel-expressing, division-arrested cells. |
| Target Type | Ion Channel |
| Product Type | EZCells™ TT |
| Family | Potassium, Calcium-Activated |
| Sub-Type | KCa1.1 |
| Class | calcium-activated potassium channel |
| Therapeutic Area | cancer, genitourinary, metabolic & gastrointestinal, pulmonary-respiratory, seizure-convulsion, vascular |
| Gene Name | KCNM1/KCNMB1 |
| Validated Assay/Platform | manual patch clamp, PatchXpress® |
| References | Wei AD, et al. International Union of Pharmacology. LII. 2005. Nomenclature and molecular relationships of calcium-activated potassium channels. Pharmacol Rev. 57:463-472. |
| EZCell Info | |
| Host cell | CHO-K1 |
| Mycoplasma Status | Negative (MycoAlert Kit) |
| Growth media | Ham's F12; 10% FBS |
| Growth characteristics | Cells remain viable 1-2 days post-thaw |
| Functional expression | Mean current amplitude ± SEM at test potential +50 mV = 3.24 ± 0.39 nA (n = 20 cells) in PatchXpress®. |
| Storage and Packaging | |
| Packaging | Cryopreserved irradiated cells, 6x106 cells |
| Storage Recommendation | liquid nitrogen |
| Quantity | 6 million cells |
