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Background
The KCNH2 gene encodes the pore-forming subunit of a voltage-gated potassium channel. HERG channels expressed in cardiac muscle cells are safety targets; hERG inhibition has been linked to drug-induced prolongation of the QT interval and torsade de pointes (a potentially lethal cardiac arrhythmia).
| General Info | |
| Synonyms | Kv11.1 |
|---|---|
| Product Description | hERG ion channel-expressing, division-arrested cells. |
| Target Type | Ion Channel |
| Product Type | EZCells™ DA |
| Family | Potassium, Voltage-Gated |
| Sub-Type | Kv11.1 |
| Class | Voltage-gated potassium channel |
| Therapeutic Area | cancer, cardiac |
| Related Services | hERG Concentration Response Assay, Ion Channel Trafficking Assays, Cardiac Ion Channel Panel™ |
| Gene Name | KCNH2 |
| Validated Assay/Platform | PatchXpress® |
| References | Gutman GA, et al. 2005. Pharmacol Rev. 57:473-508. International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. |
| EZCell Info | |
| Host cell | CHO |
| Mycoplasma Status | Negative (MycoAlert Kit) |
| Growth media | Ham's F12; 10% FBS |
| Growth characteristics | cells remain viable 1–2 days post-thaw |
| Functional expression | median K+ current amplitude = 0.45 nA |
| Storage and Packaging | |
| Packaging | Cryopreserved irradiated cells, 6x106 cells |
| Storage Recommendation | liquid nitrogen |
| Quantity | 6 million cells |
| Media | |
| Specification Sheet |  Download PDF Document |
