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Background
The human HCN2 gene encodes the pore-forming subunit of a hyperpolarization-activated, cyclic nucleotide-modulated cation channel. HCN2 channels contribute to pacemaker current that controls rhythmic excitation in the heart and brain.
| General Info | |
| Product Description | Human HCN2 hyperpolarization-gated ion channel-expressing, stable replicating cell line. |
|---|---|
| Target Type | Ion Channel |
| Product Type | Replicating Cell Line |
| Family | Hyperpolarization-gated |
| Sub-Type | HCN2 |
| Class | Hyperpolarization-gated channel |
| Therapeutic Area | cardiac, pain & inflammation, seizure-convulsion |
| Related Services | Cardiac Ion Channel Panel™, Large-scale Cryopreservation |
| Gene Name | HCN2 |
| Validated Assay/Platform | IonWorks Quattro™, PatchXpress®, QPatch HT |
| References | Hofmann F, et al. 2005. Pharmacol Rev. 57:455-462. International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels. |
| Host cell | CHO |
| Mycoplasma Status | Negative (MycoAlert Kit) |
| Storage & Packaging | |
| Packaging | Cryopreserved cells, 1-2x106 cells |
| Storage Recommendation | liquid nitrogen |
| Quantity | 1-2 million cells |
| Product Documentation | |
| Specification Sheet |  Download PDF Document |
