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Human HCN1 Hyperpolarization-Gated Channel Cell Line

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  • Voltage-dependent gating and zatebradine block in PatchXpress®: Hyperpolarization-dependent activation. Currents were elicited by test pulses from 0 to -120 mV in 10 mV decrements from holding potential, –30 mV.
  • Voltage-dependent gating and zatebradine block in PatchXpress®: Current-voltage relationship.
  • Concentration-dependent zatebradine block in PatchXpress®: HCN1 currents elicited by -120 mV test potentials in before (vehicle control) and after zatebradine application at 1 and 10 μM.
  • Concentration-dependent zatebradine block in PatchXpress®: Zatebradine concentration-response relationship (Mean ± SEM, n = 3 - 9 cells/concentration). IC50 = 0.95 μM.

Human HCN1 Hyperpolarization-Gated Channel Cell Line

  • Cat.#:
  • CT6114

Availability: In stock

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Quick Overview

The human HCN1 gene encodes the pore-forming subunit of a hyperpolarization-activated cation-selective channel. HCN1 channels contribute to pacemaker currents in the heart and brain.

Background

Human HCN1 hyperpolarization-gated ion channel-expressing, stable replicating cell line.
General Info
Synonyms hyperpolarization-activated, cyclic nucleotide-gated channel
Product Description The human HCN1 gene encodes the pore-forming subunit of a hyperpolarization-activated cation-selective channel. HCN1 channels contribute to pacemaker currents in the heart and brain.
Target Type Ion Channel
Product Type Replicating Cell Line
Family Hyperpolarization-gated
Sub-Type HCN1
Class Hyperpolarization-gated channel
Therapeutic Area pain & inflammation, seizure-convulsion
Related Services Large-scale Cryopreservation
Gene Name HCN1
Validated Assay/Platform PatchXpress®
References Hofmann F, et al. 2005. Pharmacol Rev. 57:455-462. International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels.
Host cell HEK293, tetracycline-inducible
Mycoplasma Status Negative (MycoAlert Kit)
Storage & Packaging
Packaging Cryopreserved cells, 1-2x106 cells
Storage Recommendation liquid nitrogen
Quantity 1-2 million cells
Product Documentation
Specification Sheet  Download PDF Document