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Background
The human CACNA1B gene encodes the pore-forming subunit of voltage-gated N-type Ca2+ channels. Co-expression with the β3 and α2δ1 auxiliary subunits recapitulates function in heterologous expression (CHO cells). Cav2.2 channels, widely distributed in neurons, are therapeutic targets in neuropathic and inflammatory pain.
| General Info | |
| Synonyms | N-type calcium channel |
|---|---|
| Product Description | Human Cav2.2/b3/a2d1 ion channel-expressing, division-arrested cells. |
| Target Type | Ion Channel |
| Product Type | EZCells™ TT |
| Family | Calcium, Voltage-Gated |
| Sub-Type | Cav2.2/β3/α2δ1 |
| Class | Voltage-gated calcium channel |
| Therapeutic Area | pain & inflammation |
| Gene Name | CACNA1B/CACNB3/CACNA2D1 |
| Validated Assay/Platform | PatchXpress® |
| References | Catterall WA et al. 2005. Pharmacol Rev. 57:411-25. International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels. |
| EZCell Info | |
| Host cell | CHO |
| Mycoplasma Status | Negative (MycoAlert Kit) |
| Growth media | Ham's F12; 10% FBS |
| Growth characteristics | cells remain viable 1–2 days post-thaw |
| Functional expression | median Ca2+ current amplitude = 0.27 nA |
| Storage and Packaging | |
| Packaging | Cryopreserved irradiated cells, 6x106 cells |
| Storage Recommendation | liquid nitrogen |
| Quantity | 6 million cells |
