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Background
The human CACNA1D gene encodes the pore-forming subunit of Cav1.3. CACNB3 and CACNA2D1 encode auxiliary subunits that modulate gating and pharmacological properties. The inducible expression of Kir2.1 provides a mechanism for K+-depolarization of the resting membrane potential to facilitate voltage-dependent activation of the Cav1.3 channels in FLIPR assays.
| General Info | |
| Synonyms | L-type calcium channel |
|---|---|
| Product Description | Human Cav1.3/β3/α2δ1/Kir2.1 calcium ion channel-expressing, stable replicating cell line. |
| Target Type | Ion Channel |
| Product Type | Replicating Cell Line |
| Family | Calcium, Voltage-Gated |
| Sub-Type | Cav1.3/β3/α2δ1 |
| Class | Voltage-gated calcium channel |
| Therapeutic Area | cardiac, neurodegeneration & stroke, psychiatric disorder, vascular |
| Related Services | Large-scale Cryopreservation |
| Gene Name | CACNA1D/CACNB3/CACNA2D1 + KCNJ2 |
| Validated Assay/Platform | FLIPR® |
| References | Catterall WA, et al. 2005. International Union of Pharmacology. XLVIII. Nomenclature and molecular relationships of voltage-gated calcium channels. Pharmacol Rev. 57:411-425. NCTT Assay Guidance Manual Ver. 6 (available online at http://assay.nih.gov |
| Host cell | HEK293 |
| Mycoplasma Status | Negative (MycoAlert Kit) |
| Storage & Packaging | |
| Packaging | Cryopreserved cells, 1x106 cells/vial |
| Storage Recommendation | liquid nitrogen |
| Quantity | 1 million cells |
| Product Documentation | |
| Specification Sheet |  Download PDF Document |
