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Background
The human ACCN2 gene encodes the pore-forming subunit of ASIC1a, a proton-activated, channel permeable to both Na+ and Ca2+ ions. ASIC1a channels widely expressed in the neurons of peripheral sensory and the central nervous system are therapeutic targets in pain and neurodegenerative diseases.
| General Info | |
| Synonyms | Acid-sensing (proton-gated) ion channel |
|---|---|
| Product Description | Human ASIC1a acid-sensing ion ion channel-expressing, stable replicating cell line. |
| Target Type | Ion Channel |
| Product Type | Replicating Cell Line |
| Family | Acid-Sensing |
| Sub-Type | ASIC1a |
| Class | acid-sensing ion channel |
| Therapeutic Area | neurodegeneration & stroke, pain & inflammation |
| Related Services | Large-scale Cryopreservation |
| Gene Name | ACCN2 |
| Validated Assay/Platform | PatchXpress® |
| References | Xiong ZG, et al., 2008. Curr Opin Pharmacol 8:25-32. Acid-sensing ion channels (ASICs) as pharmacological targets for neurodegenerative diseases. |
| Host cell | CHO |
| Mycoplasma Status | Negative (MycoAlert Kit) |
| Storage & Packaging | |
| Packaging | Cryopreserved cells, 1-2x106 cells |
| Storage Recommendation | liquid nitrogen |
| Quantity | 1-2 million cells |
| Product Documentation | |
| Specification Sheet |  Download PDF Document |
