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Background
The human TRPV1 gene encodes the pore-forming subunit of TRPV1, a non-selective, cation-permeable channel expressed in CNS and PNS (dorsal root ganglion) sensory neurons. TRPV1 channels are therapeutic targets in inflammatory bowel, incontinence, rheumatoid arthritis, pain, and cough.
| General Info | |
| Product Description | Human TRPV1 ion channel-expressing, stable replicating cell line. |
|---|---|
| Target Type | Ion Channel |
| Product Type | Replicating Cell Line |
| Family | TRP |
| Receptor | Vanilloid |
| Sub-Type | TRPV1 |
| Class | Transient Receptor Potential (TRP) |
| Therapeutic Area | cancer, genitourinary, metabolic & gastrointestinal, pain & inflammation, pulmonary-respiratory, vascular |
| Related Services | Large-scale Cryopreservation |
| Gene Name | TRPV1 |
| Validated Assay/Platform | FLIPR®, manual patch clamp |
| References | Clapham DE, et al. 2005. Pharmacol Rev 57: 427 - 450. International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels |
| Host cell | HEK293 |
| Mycoplasma Status | Negative (MycoAlert Kit) |
| Storage & Packaging | |
| Packaging | Cryopreserved cells, 1-2x106 cells |
| Storage Recommendation | liquid nitrogen |
| Quantity | 1-2 million cells |
| Product Documentation | |
| Specification Sheet |  Download PDF Document |
