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Background
The human P2RX4 gene encodes P2X4, an ionotropic ATP receptor that functions as an ATP-activated cation channel expressed in the CNS, alveolar macrophages, vascular endothelium, and airway smooth muscle. P2X4 receptors are therapeutic targets in treatment of neuropathic pain, asthma, and heart failure.
| General Info | |
| Product Description | Human P2X4 Purinergic Receptor-expressing, stable replicating cell line. |
|---|---|
| Target Type | Ion Channel |
| Product Type | Replicating Cell Line |
| Family | Ligand-Gated |
| Receptor | Purinergic |
| Sub-Type | P2X4 |
| Class | Ionotropic purinergic receptor |
| Therapeutic Area | cardiac, pain & inflammation, pulmonary-respiratory, vascular |
| Related Services | Large-scale Cryopreservation |
| Gene Name | P2RX4 |
| Validated Assay/Platform | FLIPR®, PatchXpress®, QPatch HT |
| References | Alexander SPH, et al., 2007. Br J Pharmocol 150 (Suppl. 1): S1 – S168. Guide to Receptors and Channels. |
| Host cell | HEK293 |
| Mycoplasma Status | Negative (MycoAlert Kit) |
| Storage & Packaging | |
| Packaging | Cryopreserved cells, 1-2x106 cells |
| Storage Recommendation | liquid nitrogen |
| Quantity | 1-2 million cells |
| Product Documentation | |
| Specification Sheet |  Download PDF Document |
