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Background
The human SCN10A/SCN3B gene encodes the pore-forming subunit of Nav1.8, a voltage-gated sodium channel expressed in the peripheral nervous system including dorsal root ganglia. The SCN3B gene encodes an auxiliary β-subunit that promotes surface expression. Nav1.8 channels are upregulated in chronic/inflammatory pain and are therapeutic targets in pain treatment.
| General Info | |
| Synonyms | PN3, SNS |
|---|---|
| Product Description | Human Nav1.8/b3 sodium ion channel-expressing, stable replicating cell line. |
| Target Type | Ion Channel |
| Product Type | Replicating Cell Line |
| Family | Sodium, Voltage-Gated |
| Sub-Type | Nav1.8/β3 |
| Class | Voltage-gated sodium channel |
| Therapeutic Area | pain & inflammation |
| Related Services | Large-scale Cryopreservation |
| Gene Name | SCN10A/SCN3B |
| Validated Assay/Platform | FLIPR® |
| References | Catterall WA, et al. 2005. Pharmacol Rev 57:397-409. International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels Zhang ZN, et al. 2008. J Cell Sci. 121:3243-3252. The voltage-gated Na |
| Host cell | CHO |
| Mycoplasma Status | Negative (MycoAlert Kit) |
| Storage & Packaging | |
| Packaging | Cryopreserved cells, 1-2x106 cells |
| Storage Recommendation | liquid nitrogen |
| Quantity | 1-2 million cells |
| Product Documentation | |
| Specification Sheet |  Download PDF Document |
