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Background
The human KCNA5 gene encodes the pore-forming subunit of Kv1.5, a voltage-gated potassium channel. A KCNA5 mutation has been linked to an inherited form of atrial fibrillation. Kv1.5 channels are widely expressed in heart, colon, kidney, vascular smooth muscle and CNS, and are therapeutic targets in atrial fibrillation, pulmonary hypertension, cancer, and multiple sclerosis.
| General Info | |
| Product Description | Human Kv1.5 potassium ion channel-expressing, stable replicating cell line (HEK). |
|---|---|
| Target Type | Ion Channel |
| Product Type | Replicating Cell Line |
| Family | Potassium, Voltage-Gated |
| Sub-Type | Kv1.5 |
| Class | Voltage-gated potassium channel |
| Therapeutic Area | cancer, cardiac, neurodegeneration & stroke, pain & inflammation, pulmonary-respiratory, vascular |
| Related Services | Cardiac Ion Channel Panel™, Ion Channel Trafficking Assays, Large-scale Cryopreservation |
| Gene Name | KCNA5 |
| Validated Assay/Platform | manual patch clamp, PatchXpress® |
| References | Gutman GA, et al. 2005. Pharmacol Rev. 57:473-508. International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. |
| Host cell | HEK293 |
| Mycoplasma Status | Negative (MycoAlert Kit) |
| Growth media | DMEM/Ham's F12; 10% FBS; 500 µg/mL G418 |
| Storage & Packaging | |
| Packaging | Cryopreserved cells, 1-2x106 cells |
| Storage Recommendation | liquid nitrogen |
| Quantity | 1-2 million cells |
| Product Documentation | |
| Specification Sheet |  Download PDF Document |
