Human Kv1.2 Potassium Channel Cell Line

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  • hKv1.2 current-voltage family recorded by PatchXpress® automated patch clamp. Whole-cell currents elicited by test pulses from -60mV to +50mV in 10mV steps from holding potential, -80 mV.
  • Concentration-response relationship for inhibition of hKv1.2 by 4-aminopyridine. Currents were elicited by test pulses to +40 mV. The IC50 value was 300 µM. Recording instrument: PatchXpress®.

Human Kv1.2 Potassium Channel Cell Line

  • Cat.#:
  • CT6132

Availability: In stock

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Quick Overview

Human Kv1.2 potassium ion channel-expressing, stable replicating cell line (HEK).

Background

The human KCNA2 gene encodes the pore-forming subunit of Kv1.2, a voltage-gated potassium channel. Kv1.2 channels expressed in neurons are therapeutic targets in multiple sclerosis.
General Info
Product Description Human Kv1.2 potassium ion channel-expressing, stable replicating cell line (HEK).
Target Type Ion Channel
Product Type Replicating Cell Line
Family Potassium, Voltage-Gated
Sub-Type Kv1.2
Class Voltage-gated potassium channel
Related Services Large-scale Cryopreservation
Gene Name KCNA2
Validated Assay/Platform PatchXpress®
References Gutman GA, et al. 2005. Pharmacol Rev. 57:473-508. International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels.
Host cell HEK293
Mycoplasma Status Negative (MycoAlert Kit)
Storage & Packaging
Packaging Cryopreserved cells, 1-2x106 cells
Storage Recommendation liquid nitrogen
Quantity 1-2 million cells
Product Documentation
Specification Sheet  Download PDF Document