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Background
The human GABRA2, GABRB3, and GABRG2 genes encode a GABA-activated, chloride-selective channel. GABAA receptors expressed in neurons are sites of action for benzodiazepines, barbiturates, and neurosteroids; and therapeutic targets in treatment of several neurological disorders including seizures, anxiety, and insomnia.
| General Info | |
| Product Description | Human GABAA (α2/β3/γ2) Receptor-expressing, stable replicating cell line. |
|---|---|
| Target Type | Ion Channel |
| Product Type | Replicating Cell Line |
| Family | Ligand-Gated |
| Sub-Type | GABAA (α2β3γ2) |
| Class | Ligand-gated channel |
| Therapeutic Area | psychiatric disorder, seizure-convulsion |
| Related Services | Large-scale Cryopreservation |
| Gene Name | GABRA2/GABRB3/GABRG2 |
| References | Olsen, RW and Sieghart W. 2008. International Union of Pharmacology. LXX. Subtypes of γ-GABAA receptors: Classification on the basis of subunit composition. Pharmacol Rev. 60:243-260. |
| Host cell | HEK293 |
| Mycoplasma Status | Negative (MycoAlert Kit) |
| Storage & Packaging | |
| Packaging | Cryopreserved cells, 1x106 cells/vial |
| Storage Recommendation | liquid nitrogen |
| Quantity | 1 million cells |
| Product Documentation | |
| Specification Sheet |  Download PDF Document |
