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Background
The human CACNA1A gene encodes the pore-forming subunit of Cav2.1, the voltage-gated P/Q-type calcium channel. CACNB4 and CACNA2D1 encode auxiliary subunits that modulate gating and pharmacological characteristics. Mutations in CACNA1A are responsible for several inherited neurologic disorders including, familial hemiplegic migraine, episodic ataxia type2, and spinocerebellar ataxia type 6 epilepsy. Cav2.1 channels expressed in neurons are therapeutic targets in pain.
| General Info | |
| Synonyms | P/Q-type calcium channel |
|---|---|
| Product Description | Human Cav2.1/β4/α2δ1 calcium ion channel-expressing, stable replicating cell line. |
| Target Type | Ion Channel |
| Product Type | Replicating Cell Line |
| Family | Calcium, Voltage-Gated |
| Sub-Type | Cav2.1/β4/α2δ1 |
| Class | Voltage-gated calcium channel |
| Therapeutic Area | pain & inflammation, seizure-convulsion |
| Related Services | Large-scale Cryopreservation |
| Gene Name | CACNA1A/CACNB4/CACNA2D1 |
| Validated Assay/Platform | IonWorks Quattro™, manual patch clamp, PatchXpress®, QPatch HT |
| References | Catterall WA, et al. 2005. Pharmacol Rev. 57:411-425. International Union of Pharmacology. XLVIII. Nomenclature and molecular relationships of voltage-gated calcium channels. |
| Host cell | CHO |
| Mycoplasma Status | Negative (MycoAlert Kit) |
| Storage & Packaging | |
| Packaging | Cryopreserved cells, 1-2x106 cells |
| Storage Recommendation | liquid nitrogen |
| Quantity | 1-2 million cells |
| Product Documentation | |
| Specification Sheet |  Download PDF Document |
