Nicotinic receptors (nAChR) are acetylcholine-activated non-selective cation channels that mediate excitatory neurotransmission. The receptor-channels are configured as hetero- or homopentamers. The human CHRNA3 and CHRNB4 genes encode a cationic-selective, ionotropic α3/β4 nicotinic acetylcholine receptor (nAChR). Channels that contain a3 subunits typically have lower Ca2+ permeability compared to those containing a7 subunits. Therefore, α7 nAChRs are particularly important in regulation of Ca2+-dependent signalling pathways. Tissue distribution also differs with α3/β4 receptors prominent in autonomic ganglia and α7 receptors widely distributed in the CNS.
|Product Description||Human α3/β4 Nicotinic Acetylcholine Receptor-expressing, stable replicating cell line.|
|Target Type||Ion Channel|
|Product Type||Replicating Cell Line|
|Related Services||Large-scale Cryopreservation|
|Genbank Accession Number||NM_000743.2 and NM_000750.3|
|References||Albuquerque EX, et al. 2009. Physiol Rev. 89:73-120. Mammalian nicotinic acetylcholine receptors: From structure to function.
Stauderman KA, et al. 1998. J Pharmacol Exp Ther. 284: 777-789. Characterization of human recombinant neuronal nicotinic ace
|Mycoplasma Status||Negative (MycoAlert Kit)|
|Storage & Packaging|
|Packaging||Cryopreserved cells, 1-2x106 cells|
|Storage Recommendation||liquid nitrogen|
|Quantity||1-2 million cells|
|Specification Sheet||Download PDF Document|