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Background
The human P2RX1 gene encodes P2X1, an ionotropic ATP receptor that functions as an ATP- or ADP-activated cation channel, expressed in smooth muscle, platelets, and sensory neurons. A P2RX1 mutation has been linked to a severe bleeding disorder arising from impaired ADP-induced platelet aggregation. P2X1 receptors are therapeutic targets in treatment of urinary incontinence and pain.
| General Info | |
| Product Description | Human P2X1 Purinergic Receptor-expressing, transiently transfected cells. |
|---|---|
| Target Type | Ion Channel |
| Product Type | EZCells™ TT |
| Family | Ligand-Gated |
| Receptor | Purinergic |
| Sub-Type | P2X1 |
| Class | Ionotropic purinergic receptor |
| Therapeutic Area | genitourinary, pain & inflammation |
| Gene Name | P2RX1 |
| Genbank Accession Number | NM_002558.2 |
| Validated Assay/Platform | manual patch clamp |
| References | Alexander SPH, et al., 2007. Br J Pharmocol 150 (Suppl. 1): S1 – S168. Guide to Receptors and Channels. |
| EZCell Info | |
| Host cell | HEK293 |
| Mycoplasma Status | Negative (MycoAlert Kit) |
| Growth media | DMEM/F12/10% FBS |
| Storage and Packaging | |
| Packaging | Cryopreserved cells, 6x106 cells/vial |
| Storage Recommendation | liquid nitrogen |
| Quantity | 6 million cells |
