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Background
The SCN4A gene encodes the pore-forming subunit of the voltage-gated, skeletal muscle Na+ channel. Nav1.4 is a therapeutic target for treatment of myotonia.
| General Info | |
| Synonyms | Skeletal muscle sodium channel, SkM1 |
|---|---|
| Product Description | Human Nav1.4 ion channel-expressing, division-arrested cells. |
| Target Type | Ion Channel |
| Product Type | EZCells™ TT |
| Family | Sodium, Voltage-Gated |
| Sub-Type | Nav1.4 |
| Class | Voltage-gated sodium channel |
| Gene Name | SCN4A |
| Validated Assay/Platform | PatchXpress® |
| References | Catterall WA, Goldin AL, Waxman SG. 2005. International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.Pharmacol Rev. 57:397-409. |
| EZCell Info | |
| Host cell | CHO-K1 |
| Mycoplasma Status | Negative (MycoAlert Kit) |
| Growth media | Ham's F12; 10% FBS |
| Growth characteristics | cells remain viable 1–2 days post-thaw |
| Functional expression | median Na+ current amplitude = 1.8 nA |
| Storage and Packaging | |
| Packaging | Cryopreserved irradiated cells, 6x106 cells |
| Storage Recommendation | liquid nitrogen |
| Quantity | 6 million cells |
