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Background
KCa2.1 - KCa2.3 (SK1, SK2, and SK3) are “small conductance”, calcium-activated, potassium-selective channels. Channel gating is relatively insensitive to membrane potential, compared with other family members (e.g. KCa1.1). SK channels expressed in neurons contribute to afterhyperpolarization that regulates repetitive firing.
| General Info | |
| Synonyms | SK3 |
|---|---|
| Product Description | Human KCa2.3 potassium ion channel-expressing, division-arrested cells. |
| Target Type | Ion Channel |
| Product Type | EZCells™ TT |
| Family | Potassium, Calcium-Activated |
| Sub-Type | KCa2.3 |
| Class | calcium-activated potassium channel |
| Therapeutic Area | seizure-convulsion, vascular |
| Gene Name | SK3 |
| Genbank Accession Number | NM_002249.4 |
| Validated Assay/Platform | FlexStation III |
| References | Barfod et al. (2001) Cloning and functional expression of a liver isoform of the small conductance Ca2+-activated K+ channel SK3. Am. J. Physiol. Cell Physiol. 280: C836-C842. Hosseini et al. (2001) SK3 is an important component of K+ channels mediat |
| EZCell Info | |
| Host cell | CHO-K1 |
| Mycoplasma Status | Negative (MycoAlert Kit) |
| Growth media | Ham's F12, 10% FBS and 1x Pen-Strep. |
| Growth characteristics | EZCells will grow 1-2 days post thaw |
| Storage and Packaging | |
| Packaging | Cryopreserved irradiated cells, 6 million cells per vial. |
| Storage Recommendation | liquid nitrogen |
| Quantity | 6 million cells |
