My Cart
You have no items in your shopping cart.
Background
GABA-A is an ionotropic gamma-aminobutyric acid receptor that forms a heteropentameric chloride-selective channel which mediates inhibitory neurotransmission. Expressed in the central nervous system, the GABA-A receptor containing the alpha-3 subunit is a therapeutic target in treatment of anxiety and pain.
| General Info | |
| Product Description | Human GABAA (a3/b2/g2) Receptor-expressing, transiently transfected cells. |
|---|---|
| Target Type | Ion Channel |
| Product Type | EZCells™ TT |
| Family | Ligand-Gated |
| Sub-Type | GABA-A (α3/β2/γ2) |
| Class | Ligand-gated cation channel |
| Therapeutic Area | pain & inflammation, psychiatric disorder |
| Gene Name | GABRA3/GABRB2/GABRG2 |
| Genbank Accession Number | NM_000808, NM_021911, NM_198904.1 |
| Validated Assay/Platform | FLIPR® |
| References | Olsen, RW and Sieghart W. 2008. Pharmacol Rev. 60:243-260. International Union of Pharmacology. LXX. Subtypes of g-aminobutyric acidA receptors: Classification on the basis of subunit composition. |
| EZCell Info | |
| Host cell | HEK293 |
| Mycoplasma Status | Negative (MycoAlert Kit) |
| Growth media | DMEM/F12/10% FBS |
| Storage and Packaging | |
| Packaging | Cryopreserved cells, 6x106 cells/vial |
| Storage Recommendation | liquid nitrogen |
| Quantity | 6 million cells |
