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Background
The human SCNN1A, B and G genes encode the heteromeric ENaC channel, a constitutively active, amiloride-sensitive Na+-selective ion channel. ENaC expressed in kidney and colon is a therapeutic target in hypertension, congestive heart disease and inflammatory bowel disease.
| General Info | |
| Synonyms | ENaC |
|---|---|
| Product Description | Human epithelial sodium ion channel-expressing, transiently transfected cells. |
| Target Type | Ion Channel |
| Product Type | EZCells™ TT |
| Family | Sodium, Epithelial |
| Sub-Type | ENaC |
| Class | epithelial sodium channel |
| Gene Name | SCNN1A, SCNN1B, SCNN1G |
| Validated Assay/Platform | manual patch clamp |
| References | Bhalla V, Hallows KR. 2008. Mechanisms of ENaC regulation and clinical implications. J Am Soc Nephrol. 19:1845-1854. |
| EZCell Info | |
| Host cell | CHO-K1 |
| Mycoplasma Status | Negative (MycoAlert Kit) |
| Growth media | Ham's F12; 10% FBS |
| Functional expression | mean current amplitude ± SEM at -110 mV= -0.43 nA ± 0.073, n = 28, in manual patch clamp. |
| Storage and Packaging | |
| Packaging | Cryopreserved irradiated cells, 6x106 cells |
| Storage Recommendation | liquid nitrogen |
| Quantity | 6 million cells |
| Media | |
| Specification Sheet |  Download PDF Document |
