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Background
The human CACNA1H gene encodes the pore-forming subunit of Cav3.2, a voltage-gated T-type calcium channel. Coexpression with the β2 and α2δ1 auxiliary subunits recapitulates function in heterologous expression (HEK cells). Inclusion of the inwardly rectifying potassium channel allows the membrane potential to be altered with changes in extracellular K+.
| General Info | |
| Synonyms | T-type calcium channel |
|---|---|
| Product Description | Human Cav3.2/β2/α2δ1/Kir2.1 calcium ion channel-expressing, transiently transfected cells. |
| Target Type | Ion Channel |
| Product Type | EZCells™ TT |
| Family | Calcium, Voltage-Gated |
| Sub-Type | Cav3.2 (T-type) |
| Class | Voltage-gated calcium channel |
| Therapeutic Area | cancer, cardiac, seizure-convulsion |
| Related Services | Cardiac Ion Channel Panel™, Large-scale Cryopreservation |
| Gene Name | CACNA1H/CACNB2/CACNA2D1/KCNJ2 |
| Validated Assay/Platform | FLIPR® |
| References | Catterall WA, et al. 2005. Pharmacol Rev. 57:411-425. International Union of Pharmacology. XLVIII. Nomenclature and molecular relationships of voltage-gated calcium channels. |
| EZCell Info | |
| Host cell | HEK293 |
| Mycoplasma Status | Negative (MycoAlert Kit) |
| Growth media | DMEM/F12/10% FBS |
| Storage and Packaging | |
| Packaging | Cryopreserved cells, 6x106 cells/vial |
| Storage Recommendation | liquid nitrogen |
| Quantity | 6 million cells |
