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Background
The human CACNA1C gene encodes the pore-forming subunit of voltage-gated L-type Ca2+ channels. Co-expession with the b2 and a2d1 auxiliary subunits recapitulates function in heterologous expression (CHO cells). Cav1.2 channels, widely distributed in cardiac and smooth muscle, and in neurons, are therapeutic targets in cardiovascular and neurological diseases.
| General Info | |
| Synonyms | L-type calcium channel |
|---|---|
| Product Description | Human Cav1.2/b2/a2d1 ion channel-expressing, division-arrested cells. |
| Target Type | Ion Channel |
| Product Type | EZCells™ DA |
| Family | Calcium, Voltage-Gated |
| Sub-Type | Cav1.2/β2/α2δ1 |
| Class | Voltage-gated calcium channel |
| Therapeutic Area | cancer, cardiac, vascular |
| Related Services | Cardiac Ion Channel Panel™ |
| Gene Name | CACNA1C/CACNB2/CACNA2D1 |
| Validated Assay/Platform | manual patch clamp |
| References | Catterall WA et al. 2005. Pharmacol Rev. 57:411-25. International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels. |
| EZCell Info | |
| Host cell | CHO-K1 |
| Mycoplasma Status | Negative (MycoAlert Kit) |
| Growth media | Ham's F12; 10% FBS |
| Growth characteristics | cells remain viable 1–2 days post-thaw |
| Functional expression | median Ca2+ current amplitude = 0.6 nA |
| Storage and Packaging | |
| Packaging | Cryopreserved irradiated cells, 6x106 cells |
| Storage Recommendation | liquid nitrogen |
| Quantity | 6 million cells |
| Media | |
| Specification Sheet |  Download PDF Document |
