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Background
The human CACNA1C gene encodes the pore-forming subunit of voltage-gated L-type Ca2+ channels. Co-expression with the β2 and α2δ1 auxiliary subunits recapitulates function in heterologous expression (CHO cells). Cav1.2 channels, widely distributed in cardiac and smooth muscle, and in neurons, are therapeutic targets in cardiovascular and neurological diseases.
| General Info | |
| Synonyms | L-type calcium channel |
|---|---|
| Product Description | Human Cav1.2/β2/α2δ1 ion channel-expressing, transiently transfected cells. |
| Target Type | Ion Channel |
| Product Type | EZCells™ TT |
| Family | Calcium, Voltage-Gated |
| Sub-Type | Cav1.2/β2/α2δ |
| Class | Voltage-gated calcium channel |
| Therapeutic Area | cancer, cardiac, vascular |
| Gene Name | CACNA1C/CACNB2/CACNA2D1 |
| Validated Assay/Platform | manual patch clamp |
| References | Catterall WA et al. 2005. International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels. Pharmacol Rev. 57:411-25. |
| EZCell Info | |
| Host cell | HEK293 |
| Mycoplasma Status | Negative (MycoAlert Kit) |
| Growth media | DMEM/F12; 10% FBS |
| Functional expression | Mean current amplitude ± SEM at +10 mV = 0.51 ± 0.073 nA, n = 11 cells. |
| Storage and Packaging | |
| Packaging | Cryopreserved cells, 3 x 106 cells |
| Storage Recommendation | liquid nitrogen |
| Quantity | 3 million cells |
| Media | |
| Specification Sheet |  Download PDF Document |
