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Background
The human TRPM8 gene encodes the pore-forming subunit of TRPM8, a non-selective, cation-permeable channel, expressed in tumor cells, sensory neurons, prostate, liver and bladder. TRPM8 channels ar therapeutic targets in overactive bladder and pain.
| General Info | |
| Product Description | Human TRPM8 ion channel-expressing, division-arrested cells. |
|---|---|
| Target Type | Ion Channel |
| Product Type | EZCells™ TT |
| Family | TRP |
| Sub-Type | TRPM8 |
| Class | Transient Receptor Potential (TRP) |
| Therapeutic Area | cancer, genitourinary, pain & inflammation |
| Gene Name | TRPM8 |
| Genbank Accession Number | NM_024080.4 |
| Validated Assay/Platform | FlexStation III |
| References | Mälkiä A, Madrid R, Meseguer V, et al.. Bidirectional shifts of TRPM8 channel gating by temperature and chemical agents modulate the cold sensitivity of mammalian thermoreceptors. J Physiol. 2007 581:155-174 |
| EZCell Info | |
| Host cell | CHO |
| Mycoplasma Status | Negative (MycoAlert Kit) |
| Growth media | Ham's F12, 10% FBS and induced with 1 µg/mL tetracycline for 24 hour. |
| Growth characteristics | cells remain viable 1–2 days post-thaw |
| Storage and Packaging | |
| Packaging | Cryopreserved irradiated cells, 6x106 cells |
| Storage Recommendation | liquid nitrogen |
| Quantity | 6 million cells |
