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Background
The human GRIN1/GRIN2B genes encode the cationic-selective, n-methyl-d-aspartic acid receptor-channel expressed in the CNS. NMDA receptors are therapeutic targets in treatment of neurological disorders including seizure, pain, and Alzheimer's disease.
| General Info | |
| Synonyms | GluN1/GluN2B |
|---|---|
| Product Description | Human NMDA (NR1/NR2B) Receptor-expressing, stable replicating cell line. |
| Target Type | Ion Channel |
| Product Type | Replicating Cell Line |
| Family | Ligand-Gated |
| Receptor | Glutamate |
| Sub-Type | NMDA (NR1/NR2B) |
| Class | Ligand-gated cation channel |
| Therapeutic Area | neurodegeneration & stroke, pain & inflammation, psychiatric disorder, seizure-convulsion |
| Related Services | Large-scale Cryopreservation |
| Gene Name | GRIN1/GRIN2B |
| Validated Assay/Platform | FLIPR® |
| References | Danysz W and Parsons CG. 1998. Pharmacol Rev. 50:597-664. Glycine and N-methyl-d-aspartate receptors: Physiological significance and possible therapeutic applications. |
| Host cell | HEK293 |
| Mycoplasma Status | Negative (MycoAlert Kit) |
| Growth media | DMEM/Ham's F12; 10% FBS; 500 µg/mL G418 |
| Storage & Packaging | |
| Packaging | Cryopreserved cells, 1-2x106 cells |
| Storage Recommendation | liquid nitrogen |
| Quantity | 1-2 million cells |
| Product Documentation | |
| Specification Sheet |  Download PDF Document |
