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Human Nav1.2 Sodium Channel Cell Line

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  • Pharmacological characteristics of hNav1.2 recorded by IonWorks Quattro®: Pre-conditioning depolarization enhances sensitivity to lidocaine and carbamazepine (use-dependent block augmentation). Aa-Ad: Block of hNav1.2 channels by lidocaine and carbamazepine measured using the stimulus voltage pattern shown in Aa (holding potential, -80 mV). The pulse pattern was repeated twice: once before and again after five minutes of test article (TA) exposure. Peak current amplitudes were measured at the first test pulse (TP1; tonic block, panel Ab), the 11th test pulse (TP11; frequency-dependent block, panel Ac), and the 12th test pulse (TP12, inactivated state block, panel Ad).
  • Ba: Concentration-response relationships for lidocaine block. IC50 values for tonic, frequency-dependent, and inactivated state block, respectively, 1228 µM, 113 µM (10 Hz stimulation frequency), and 11 µM. Data are presented as mean ± SD (n = 4-8). Recording instrument: IonWorks Quattro®.
  • Bb: Concentration-response relationships for carbamazepine block. IC50 values for tonic, frequency-dependent, and inactivated state block, respectively, were 434 µM, 331 µM (10 Hz stimulation frequency), and 28 µM. Data are presented as mean ± SD (n = 4 - 8). Recording instrument: IonWorks Quattro®.

Human Nav1.2 Sodium Channel Cell Line

  • Cat.#:
  • CT6010

Availability: In stock

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Quick Overview

Human Nav1.2 sodium ion channel-expressing, stable replicating cell line (CHO).

Background

The human SCN2A gene encodes the pore-forming subunit of Nav1.2, a voltage-gated sodium channel expressed in CNS neurons. SCN2A mutations are associated with benign familial neonatal-infantile seizures. Nav1.2 channels are therapeutic targets in seizure, stroke, and pain.
General Info
Synonyms Brain type II
Product Description Human Nav1.2 sodium ion channel-expressing, stable replicating cell line (CHO).
Target Type Ion Channel
Product Type Replicating Cell Line
Family Sodium, Voltage-Gated
Sub-Type Nav1.2
Class Voltage-gated sodium channel
Therapeutic Area neurodegeneration & stroke, pain & inflammation, seizure-convulsion
Related Services Large-scale Cryopreservation
Gene Name SCN2A
Validated Assay/Platform IonWorks Quattro™, QPatch HT
References Catterall WA, et al. 2005. Pharmacol Rev 57:397-409. International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels
Host cell CHO
Mycoplasma Status Negative (MycoAlert Kit)
Storage & Packaging
Packaging Cryopreserved cells, 1-2x106 cells
Storage Recommendation liquid nitrogen
Quantity 1-2 million cells
Product Documentation
Specification Sheet  Download PDF Document