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Background
The human SCN1A gene encodes the pore-forming subunit of Nav1.1, a voltage-gated sodium channel expressed in CNS neurons and dorsal root ganglia. Mutations in SCN1A cause several types of epilepsies (generalized epilepsy with febrile seizures, severe myoclonic epilepsy in infancy) and some forms of familial hemiplegic migraine. Nav1.1 channels are therapeutic targets in seizure, stroke, and pain.
| General Info | |
| Synonyms | Brain type I |
|---|---|
| Product Description | Human Nav1.1 sodium ion channel-expressing, stable replicating cell line (CHO). |
| Target Type | Ion Channel |
| Product Type | Replicating Cell Line |
| Family | Sodium, Voltage-Gated |
| Sub-Type | Nav1.1 |
| Class | Voltage-gated sodium channel |
| Therapeutic Area | neurodegeneration & stroke, pain & inflammation, seizure-convulsion |
| Related Services | Large-scale Cryopreservation |
| Gene Name | SCN1A |
| Validated Assay/Platform | IonWorks Quattro™, QPatch HT |
| References | Catterall WA, et al. 2005. Pharmacol Rev 57:397-409. International Union of Pharmacology. XLVII. Nomenclature and structure-runction relationships of voltage-gated sodium channels |
| Host cell | CHO |
| Mycoplasma Status | Negative (MycoAlert Kit) |
| Storage & Packaging | |
| Packaging | Cryopreserved cells, 1-2x106 cells |
| Storage Recommendation | liquid nitrogen |
| Quantity | 1-2 million cells |
| Product Documentation | |
| Specification Sheet |  Download PDF Document |
