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Background
The human KCNJ2 gene encodes the pore-forming subunit of Kir2.1, an inwardly rectifying potassium channel. Mutations in KCNJ2 have been linked to inherited cardiac diseases including Andersens syndrome (a form of long QT with neurologic involvement), Short QT syndrome, and familial atrial fibrillation. Kir2.1 channels expressed in heart are anti-targets in cardiac risk assessment.
| General Info | |
| Product Description | Human Kir2.1 potassium ion channel-expressing, stable replicating cell line (CHO). |
|---|---|
| Target Type | Ion Channel |
| Product Type | Replicating Cell Line |
| Family | Potassium, Inward Rectifier |
| Sub-Type | Kir2.1 |
| Class | Inward rectifier potassium channel |
| Therapeutic Area | cardiac, vascular |
| Related Services | Cardiac Ion Channel Panel™, Ion Channel Trafficking Assays, Large-scale Cryopreservation |
| Gene Name | KCNJ2 |
| Validated Assay/Platform | IonWorks Quattro™, QPatch HT |
| References | Kubo Y, et al. 2005. Pharmacol Rev. 57:509-526. International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels. |
| Host cell | CHO |
| Mycoplasma Status | Negative (MycoAlert Kit) |
| Storage & Packaging | |
| Packaging | Cryopreserved cells, 1-2x106 cells |
| Storage Recommendation | liquid nitrogen |
| Quantity | 1-2 million cells |
| Product Documentation | |
| Specification Sheet |  Download PDF Document |
