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Background
The human KCNMA1 gene encodes the pore-forming subunit of KCa1.1, a calcium-activated BK potassium channel. KCa1.1 channels, widely distributed, are therapeutic targets in stroke, seizure, urinary incontinence, asthma, hypertension, gastric dysmotility, schizophenia, and prostate cancer.
| General Info | |
| Synonyms | BK |
|---|---|
| Product Description | Human KCa1.1 potassium ion channel-expressing, stable replicating cell line. |
| Target Type | Ion Channel |
| Product Type | Replicating Cell Line |
| Family | Potassium, Calcium-Activated |
| Sub-Type | KCa1.1 |
| Class | calcium-activated potassium channel |
| Therapeutic Area | cancer, genitourinary, metabolic & gastrointestinal, pain & inflammation, pulmonary-respiratory, seizure-convulsion, vascular |
| Related Services | Large-scale Cryopreservation |
| Gene Name | KCNMA1 |
| Validated Assay/Platform | PatchXpress® |
| References | Wei AD, et al. 2005. Pharmacol Rev. 57:463-472. International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium activated-potassium channels. |
| Host cell | CHO-K1 |
| Mycoplasma Status | Negative (MycoAlert Kit) |
| Storage & Packaging | |
| Packaging | Cryopreserved cells, 1-2x106 cells |
| Storage Recommendation | liquid nitrogen |
| Quantity | 1-2 million cells |
| Product Documentation | |
| Specification Sheet |  Download PDF Document |
