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Background
The HCN4 gene encodes the pore-forming subunit of a hyperpolarization-gated, cyclic nucleotide-sensitive, non-selective cation channel. HCN4 channels expressed in the heart contribute to the pacemaker current (Ih) and are therapeutic targets for treatment of cardiac ischemia and angina.
| General Info | |
| Synonyms | hyperpolarization-activated, cyclic nucleotide-gated channel |
|---|---|
| Product Description | Human HCN4 ion channel-expressing, division-arrested cells. |
| Target Type | Ion Channel |
| Product Type | EZCells™ TT |
| Family | Hyperpolarization-gated |
| Sub-Type | HCN4 |
| Class | Hyperpolarization-gated channel |
| Therapeutic Area | cardiac |
| Related Services | Cardiac Ion Channel Panel™ |
| Gene Name | HCN4 |
| Validated Assay/Platform | PatchXpress® |
| References | Hofmann F, et al. 2005. Pharmacol Rev. 57:455 - 462. International Union of Pharmacology. LI. Nomenclature and molecular relationships of cyclic nucleotide-regulated channels. |
| EZCell Info | |
| Host cell | CHO |
| Mycoplasma Status | Negative (MycoAlert Kit) |
| Growth media | Ham's F12; 10% FBS |
| Growth characteristics | cells remain viable 1–2 days post-thaw |
| Functional expression | median current amplitude = 0.7 nA |
| Storage and Packaging | |
| Packaging | Cryopreserved irradiated cells, 6x106 cells |
| Storage Recommendation | liquid nitrogen |
| Quantity | 6 million cells |
