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Background
The human HCN2 gene encodes the pore-forming subunit of a hyperpolarization-activated, cyclic nucleotide-modulated cation channel. HCN2 channels contribute to pacemaker current that controls rhythmic excitation in the heart and brain.
| General Info | |
| Synonyms | hyperpolarization-activated, cyclic nucleotide-gated channel |
|---|---|
| Product Description | Human HCN2 ion channel-expressing, division-arrested cells. |
| Target Type | Ion Channel |
| Product Type | EZCells™ TT |
| Family | Hyperpolarization-gated |
| Sub-Type | HCN2 |
| Class | Hyperpolarization-gated channel |
| Therapeutic Area | cardiac, pain & inflammation, seizure-convulsion |
| Gene Name | HCN2 |
| Validated Assay/Platform | PatchXpress® |
| References | Hofmann F, et al. 2005. Pharmacol Rev. 57:455 - 462. International Union of Pharmacology. LI. Nomenclature and molecular relationships of cyclic nucleotide-regulated channels. |
| EZCell Info | |
| Host cell | CHO |
| Mycoplasma Status | Negative (MycoAlert Kit) |
| Growth media | Ham's F12; 10% FBS |
| Growth characteristics | cells remain viable 1–2 days post-thaw |
| Functional expression | median current amplitude = 1.6 nA |
| Storage and Packaging | |
| Packaging | Cryopreserved irradiated cells, 6 million cells per vial |
| Storage Recommendation | liquid nitrogen |
| Quantity | 6 million cells |
