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Background
The human CACNA1B gene encodes the pore-forming subunit of Cav2.2, the voltage-gated N-type calcium channel. CACNB3 and CACNA2D1 encode auxiliary subunits that modulate gating and pharmacological properties. Cav2.2 channels expressed in CNS neurons are therapeutic targets in pain.
| General Info | |
| Synonyms | N-type calcium channel |
|---|---|
| Product Description | Human Cav2.2/β3/α2δ1 calcium ion channel-expressing, stable replicating cell line. |
| Target Type | Ion Channel |
| Product Type | Replicating Cell Line |
| Family | Calcium, Voltage-Gated |
| Sub-Type | Cav2.2/β3/α2δ1 |
| Class | Voltage-gated calcium channel |
| Therapeutic Area | pain & inflammation |
| Related Services | Large-scale Cryopreservation |
| Gene Name | CACNA1B/CACNB3/CACNA2D1 |
| Validated Assay/Platform | IonWorks Quattro™, manual patch clamp, PatchXpress®, QPatch HT |
| References | Catterall WA, et al. 2005. Pharmacol Rev. 57:411-425. International Union of Pharmacology. XLVIII. Nomenclature and molecular relationships of voltage-gated calcium channels. |
| Host cell | CHO |
| Mycoplasma Status | Negative (MycoAlert Kit) |
| Storage & Packaging | |
| Packaging | Cryopreserved cells, 1-2x106 cells |
| Storage Recommendation | liquid nitrogen |
| Quantity | 1-2 million cells |
| Product Documentation | |
| Specification Sheet |  Download PDF Document |