My Cart
You have no items in your shopping cart.
Background
The human CACNA1B gene encodes the pore-forming subunit of Cav2.2, the voltage-gated N-type calcium channel. Inclusion of auxiliary subunits modulate gating and pharmacological properties, while the inwardly rectifying potassium channel allows the membrane potential to be altered with changes in extracellular K+. Cav2.2 channels expressed in CNS neurons are therapeutic targets in pain.
| General Info | |
| Synonyms | N-type calcium channel |
|---|---|
| Product Description | Human Cav2.2/β3/α2δ1/Kir2.1 calcium ion channel-expressing, transiently transfected cells. |
| Target Type | Ion Channel |
| Product Type | EZCells™ TT |
| Family | Calcium, Voltage-Gated |
| Sub-Type | Cav2.2 |
| Class | Voltage-gated calcium channel |
| Therapeutic Area | pain & inflammation |
| Validated Assay/Platform | FLIPR® |
| References | Catterall WA, et al. 2005. Pharmacol Rev. 57:411-425. International Union of Pharmacology. XLVIII. Nomenclature and molecular relationships of voltage-gated calcium channels. |
| EZCell Info | |
| Host cell | HEK293 |
| Mycoplasma Status | Negative (MycoAlert Kit) |
| Growth media | DMEM/F12/10% FBS |
| Storage and Packaging | |
| Packaging | Cryopreserved cells, 6x106 cells |
| Storage Recommendation | liquid nitrogen |
| Quantity | 6 million cells |
