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Background
The human ACCN2 gene encodes the pore-forming subunit of ASIC1a, a proton-activated, channel permeable to both Na+ and Ca2+ ions. ASIC1a channels widely expressed in the neurons of peripheral sensory and the central nervous system are therapeutic targets in pain and neurodegenerative diseases.
| General Info | |
| Synonyms | Acid-sensing (proton-gated) ion channel |
|---|---|
| Product Description | Human ASIC1a ion channel-expressing, division-arrested cells. |
| Target Type | Ion Channel |
| Product Type | EZCells™ TT |
| Family | Acid-Sensing |
| Sub-Type | ASIC1a |
| Class | acid-sensing ion channel |
| Therapeutic Area | neurodegeneration & stroke, pain & inflammation |
| Gene Name | ACCN2 |
| Validated Assay/Platform | PatchXpress® |
| References | Gutman GA, et al. 2005. Pharmacol Rev. 57:473-508. International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. |
| EZCell Info | |
| Host cell | CHO-K1 |
| Mycoplasma Status | Negative (MycoAlert Kit) |
| Growth media | Ham's F12; 10% FBS |
| Growth characteristics | cells remain viable 1–2 days post-thaw |
| Functional expression | Mean current amplitude ± SEM = -3.23 ± 0.22 nA at pH 5.5, (n = 34 cells) |
| Storage and Packaging | |
| Packaging | Cryopreserved irradiated cells, 6x106 cells |
| Storage Recommendation | liquid nitrogen |
| Quantity | 6 million cells |
