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Background
The human SCN9A gene encodes the pore-forming subunit of Nav1.7, a voltage-gated sodium channel. Mutations in SCN9A channels have been linked to several inherited diseases including erythromelalgia (vasodilation with burning pain), paroxysmal extreme pain disorder, and congenital indifference to pain). Nav1.7, upregulated in prostatic cancer and inflammation, is a cancer biomarker and a therapeutic target in treatment of pain.
| General Info | |
| Synonyms | PN1 |
|---|---|
| Product Description | Mouse monoclonal antibody to the Nav1.7 sodium ion channel |
| Target Type | Ion Channel |
| Product Type | Antibody |
| Family | Sodium, Voltage-Gated |
| Sub-Type | Nav1.7 |
| Class | Voltage-gated sodium channel |
| Therapeutic Area | cancer, pain & inflammation |
| Gene Name | SCN9A |
| Validated Assay/Platform | ICC, IP, WB |
| References | Hille B. (2001) Ion Channels of Excitable Membranes, 3rd Ed., Sinauer Associated Inc.: Sunderland, MA USA. Dray A. (2008) Br. J. Anaesth. 101(1): 48-58. Dray A., Read S.J (2007) Arthritis Res. Ther. 9(3): 212. 5. Samuels M.E., teMorshe R.H., Lyn |
| Antibody Info | |
| Immunogen | Fusion protein amino acids 1751-1946 (cytoplamic C-terminus) of human Nav1.7 (also known as channel protein type 9 subunit alpha, neuroendocrine sodium channel, hNE-a and peripheral sodium channel 1, accession number Q15858) |
| Host and Subclass | Mouse monoclonal, IgG1 |
| Specificity | ~230kDa. No cross reactivity against other Nav channels |
| Species cross-reactivity | Human, Mouse, Mouse |
| Format | Protein G Purified. In PBS pH7.4, 50% glycerol and 0.09% sodium azide. |
| Recommended Assay Conditions | Concentration and working dilution 1mg/µL; WB: 1-10ug/µL (if results are off, try using the lysate without boiling); IHC/ICC: 0.1-1.0ug/µL (Perox), 1.0-10ug/µL (IF) |
| Storage and Packaging | |
| Storage Recommendation | -20°C |
| Stability | 1 year+ |
| Quantity | 100 µg |