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Background
The human KCNQ4 gene encodes the pore-forming subunit of Kv7.4, a voltage-gated potassium channel. KCNQ4 loss-of-function mutations cause hereditary deafness. Kv7.4 channels expressed in neurons are therapeutic targets in seizure.
| General Info | |
| Product Description | Mouse monoclonal antibody to the KCNQ4 potassium ion channel. 1 μg/mL was sufficient for detection of KCNQ4 in 10μg of COS-1 cell lysate transiently expressing KCNQ4 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. |
|---|---|
| Target Type | Ion Channel |
| Product Type | Antibody |
| Family | Potassium Channel, Voltage-Gated |
| Sub-Type | KCNQ4 |
| Class | Voltage-gated potassium channel |
| Therapeutic Area | seizure-convulsion |
| Validated Assay/Platform | ICC, IP, WB |
| References | Hille B. (2001) Ion Channels of Excitable Membranes, 3rd Ed., Sinauer Associated Inc.: Sunderland, MA USA. Hernandez C.C., Zaiko O., Tolstykh G.P., Shapiro M.S. (2008) J Physiol. 586(7): 1811-1821. Kharkovets T., et al. (2006) EMBO J. 25(3): 642 |
| Antibody Info | |
| Immunogen | Fusion protein amino acid 2-77 of human KCNQ4 (Kv7.4, KvLQT4, accession number P56696) |
| Host and Subclass | Mouse monoclonal, IgG1 |
| Specificity | ~77kDa. |
| Species cross-reactivity | Human, Mouse, Rat. |
| Format | Protein G Purified. In PBS pH7.4, 50% glycerol and 0.09% sodium azide. |
| Recommended Assay Conditions | Concentration and working dilution 1mg/mL; WB: 1-10μg/mL; IHC/ICC: 0.1-1.0μg/mL (Perox), 1.0-10μg/mL (IF) |
| Storage and Packaging | |
| Storage Recommendation | -20°C |
| Stability | 1 year+ |
| Quantity | 100 µg |