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Background
The human KCNQ1 gene encodes the pore-forming subunit of Kv7.1, a voltage-gated potassium channel (also known as KvLQT1). Mutations in KCNQ1 cause an inherited form of long QT syndrome, type 1. KCNQ1 channels expressed in the heart are anti-targets in cardiac risk assessment.
| General Info | |
| Synonyms | KvLQT1 |
|---|---|
| Product Description | Mouse monoclonal antibody to the KCNQ1 potassium ion channel |
| Target Type | Ion Channel |
| Product Type | Antibody |
| Family | Potassium Channel, Voltage-Gated |
| Sub-Type | KCNQ1 |
| Class | Voltage-gated potassium channel |
| Gene Name | KCNQ1 |
| Validated Assay/Platform | IHC, IP, WB |
| References | Hille B. (2001) Ion Channels of Excitable Membranes, 3rd Ed., Sinauer Associated Inc. :Sunderland, MA USA. Lang F., Vallon V., Knipper M., Wagenmann P. (2007) Am J Physiol. 293(4): C1187-1208. Kurokawa J., et al. (2009) Channels (Austin). 3(1): |
| Antibody Info | |
| Immunogen | Fusion protein amino acid 2- 101 of human KCNQ1 (Kv7.1, KvLQT1, accession number P51787) |
| Host and Subclass | Mouse monoclonal, IgG1 |
| Specificity | ~75kDa. |
| Species cross-reactivity | Human, Mouse, Mouse |
| Format | Protein G Purified. In PBS pH7.4, 50% glycerol and 0.09% sodium azide. |
| Recommended Assay Conditions | Concentration and working dilution 1mg/µL; WB: 1-10ug/µL (if results are off, try using the lysate without boiling); IHC/ICC: 0.1-1.0ug/µL (Perox), 1.0-10ug/µL (IF) |
| Storage and Packaging | |
| Storage Recommendation | -20°C |
| Stability | 1 year+ |
| Quantity | 100 µg |