My Cart
You have no items in your shopping cart.
Recently Viewed Products
Background
The human HCN4 gene encodes the pore-forming subunit of a hyperpolarization-activated cation channel. HCN4 channels contribute to pacemaker currents in the heart and brain.
| General Info | |
| Synonyms | hyperpolarization-activated, cyclic nucleotide-gated channel |
|---|---|
| Product Description | Mouse monoclonal antibody to the HCN4 cyclic nucleotide-gated ion channel |
| Target Type | Ion Channel |
| Product Type | Antibody |
| Family | Hyperpolarization-gated |
| Sub-Type | HCN4 |
| Class | Hyperpolarization-gated channel |
| Therapeutic Area | cardiac |
| Related Services | Cardiac Ion Channel Panel™ |
| Gene Name | HCN4 |
| Validated Assay/Platform | ICC, IHC, WB |
| References | Hille B. (2001) Ion Channels of Excitable Membranes, 3rd Ed., Sinauer Associated Inc.: Sunderland, MA USA. Zong X., et al. (2005) J Biol Chem. 280(40): 34224-34232 |
| Antibody Info | |
| Immunogen | Fusion protein amino acids 1019-1108 (cytoplasmic C-terminus) of rat HCN4 (also known as potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, brain cyclic nucleotide-gated channel 3 and BCNG-3, accession number Q9JKA7) |
| Host and Subclass | Mouse monoclonal, IgG1 |
| Specificity | ~1 30kDa. No cross reactivity against other HCNs |
| Species cross-reactivity | Human, Mouse, Mouse |
| Format | Protein G Purified. In PBS pH7.4, 50% glycerol and 0.09% sodium azide. |
| Recommended Assay Conditions | Concentration and working dilution 1mg/µL; WB: 1-10ug/µL (if results are off, try using the lysate without boiling); IHC/ICC: 0.1-1.0ug/µL (Perox), 1.0-10ug/µL (IF) |
| Storage and Packaging | |
| Storage Recommendation | -20°C |
| Stability | 1 year+ |
| Quantity | 100 µg |